The project impact is represented by its valuable contribution to bring in front a new bone substitute:3D composite scaffolds for bone regeneration in osteoporosis. The project will open opportunities to use these scaffolds for therapeutic approaches in fractures and will contribute to increasing the quality of life and social reintegration considering the fact that worldwide 40% of osteoporotic fractures occur in people of working age.
The main objective of the project is to develop biodegradable and bioactive 3D composite scaffolds for bone regeneration in osteoporosis
- Objective 1: Preparation of 3D composite scaffolds based on biopolymers, such as carboxymethyl guar gum (CMGG) and calcium phosphates. Scaffolds based on CMGG have notable properties to sustain cell adhesion and proliferation, but have never been subjected to in vivo preclinical studies.
- Objective 2: Incorporation of bioactive principles, like growth factors, in the 3D composite scaffolds, these molecules being crucial in the natural remodeling of bone.
- Objective 3: In vitro and in vivo evaluation of scaffolds in order to confirm the osteogenic potential.